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Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen (Probable). Associates with FREE1 and ELC to perform function in the ESCRT-I complex. Binds ubiquitin in vitro (PubMed:26902184). Plays a role in the biogenesis of vacuole and multivesicular bodies (MVBs) (PubMed:26342016, PubMed:26324913). Required for the endosomal location of AMSH3 (PubMed:26324913). Mediates high-affinity phosphate transporter trafficking to maintain phosphate homeostasis. Regulates vacuolar degradation of PHT1-1 (PubMed:26342016).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ALIX; AtBRO1; BRO domain-containing protein 1; SPHR1; Vacuolar-sorting protein BRO1
基因别名: ALIX; AT1G15130; BRO1; F9L1.7; F9L1_7; SPHR1
UniProt ID: (Arabidopsis) F4HXZ1
Entrez Gene ID: (Arabidopsis) 838077