Proteintech

Bcl-XL Monoclonal Antibody (4C12A6)

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Bcl-XL Monoclonal Antibody (4C12A6)

产品信息

66020-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000-1:20,000
查看16篇已发表文章 16篇已发表文章

免疫组化 (IHC)

-
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:600
-

免疫细胞化学 (ICC/IF)

1:10-1:100
-

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells
-

免疫沉淀 (IP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

4C12A6

抗原

Bcl-XL Fusion Protein Ag18037 (1-233 aa encoded by BC019307)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MSQSNRELV VDFLSYKLSQ KGYSWSQFSD VEENRTEAPE GTESEMETPS AINGNPSWHL ADSPAVNGAT GHSSSLDARE VIPMAAVKQA LREAGDEFEL RYRRAFSDLT SQLHITPGTA YQSFEQVVNE LFRDGVNWGR IVAFFSFGGA LCVESVDKEM QVLVSRIAAW MATYLNDHLE PWIQENGGWD TFVELYGNNA AAESRKGQER FNRWFLTGMT VAGVVLLGSL FSRK (1-233 aa encoded by BC019307)

靶标信息

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B-cell leukemia/lymphoma x; Bcl-2-like protein 1; bcl-xS; Bcl2-L-1; BCL2-like 1; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3

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基因别名: Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCL2L1; BCLX; PPP1R52

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UniProt ID: (Human) Q07817, (Mouse) Q64373

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Entrez Gene ID: (Human) 598, (Mouse) 12048

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功能
protein binding protein kinase binding identical protein binding protein homodimerization activity protein heterodimerization activity BH3 domain binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process BH domain binding MDM2/MDM4 family protein binding
参与通路
cytokinesis ovarian follicle development in utero embryonic development release of cytochrome c from mitochondria endocytosis mitotic cell cycle checkpoint germ cell development spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes fertilization suppression by virus of host apoptotic process response to cytokine growth negative regulation of apoptotic process negative regulation of neuron apoptotic process response to cycloheximide regulation of mitochondrial membrane permeability neuron apoptotic process regulation of mitochondrial membrane potential cellular process regulating host cell cycle in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of establishment of protein localization to plasma membrane negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process negative regulation of execution phase of apoptosis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway response to ischemia apoptotic process response to radiation response to virus regulation of apoptotic process positive regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of anoikis
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