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Invitrogen
Bcl-xL Polyclonal Antibody
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Bcl-xL Antibody (PA1-25967) in WB
Western blot analysis of BCL-XL in E coli-derived fusion protein using a BCL-XL polyclonal antibody (Product # PA1-25967) at a dilution of 1:2000 followed by detection using a Goat anti-IgY-HRP secondary antibody at a dilution of 1:1000 and colorimetric detection.
产品信息
PA1-25967
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 20-150 of human Bcl xL.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-25967 detects Bcl xL from human samples.
PA1-25967 has been successfully used in Western blot procedures. The predicted molecular weight is 28 kDa.
The PA1-25967 immunogen is a synthetic peptide corresponding to residues 20-150 of human Bcl xL.
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
靶标信息
BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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