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Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: APG6; beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); Beclin-1; myosin-like BCL2 interacting protein
基因别名: becn1; zgc:73097
UniProt ID: (Zebrafish) F1RCP1
Entrez Gene ID: (Zebrafish) 393846