Proteintech

Bora Polyclonal Antibody

Name: Bora Polyclonal Antibody
Brand: Proteintech
SKU: 26866-1-AP

1 篇参考文献

查看其他16个Bora抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

图: 1 / 2

Bora Antibody (26866-1-AP) in WB

Jurkat cells were subjected to SDS PAGE followed by western blot with 26866-1-AP (Bora antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Immunogen image

Immunogen Image Bora Polyclonal Antibody

产品信息

26866-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Bora Fusion Protein Ag19123 (213-559 aa encoded by BC056876)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: PGSPHSGVQ TSLEMFYSID LSPVKCRSPL QTPSSGQFSS SPIQASAKKY SLGSITSPSP ISSPTFSPIE FQIGETPLSE QRKFTVHSPD ASSGTNSNGI TNPCIRSPYI DGCSPIKNWS PMRLQMYSGG TQYRTSVIQI PFTLETQGED EEDKENIPST DVSSPAMDAA GIHLRQFSNE ASTHGTHLVV TAMSVTQNQS SASEKELALL QDVEREKDNN TVDMVDPIEI ADETTWIKEP VDNGSLPMTD FVSGIAFSIE NSHMCMSPLA ESSVIPCESS NIQMDSGYNT QNCGSNIMDT VGAESYCKES DAQTCEVESK SQAFNMKQDH TTQRCWMKTA SPFQCSSP (213-559 aa encoded by BC056876)

靶标信息

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。