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Invitrogen
C14orf129 Polyclonal Antibody
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C14orf129 Antibody (PA5-60218) in WB
Molecular and cellular biology 2022 -
FIG 2 Generation of Atg2b and Gskip single-knockout mice. (A) Positions of guide RNA (gRNA)-targeted sequences in mouse Atg2b and Gskip and sequences of the mutant alleles from Atg2b - and Gskip -deficient mice. Each mutation is highlighted. (B) Immunoblot analysis. Homogenates of the livers and brains of mice with the indicated genotypes were subjected to SDS-PAGE, followed by immunoblot analysis with anti... View More
产品信息
PA5-60218
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human C14orf129
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA DDVAYINVET
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 94%.
靶标信息
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
