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Proteintech
C1orf106 Polyclonal Antibody
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产品信息
21506-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C1orf106 Fusion Protein Ag15987 (314-663 aa encoded by BC106877)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: PERAPVQNS PWKETSLDHP YEKPRKSSEP WSESSSPATT PQDGPSASSL WLLEPASYHV VPIRGVPGQW QGRTSAPATP EIQGRRGQSQ SLRVDSFRAG PEGRGRSAFP RRRPTHYTVT VPDSCFPATK PPLPHAACHS CSEDSGSDVS SISHPTSPGS SSPDISFLQP LSPPKTHRHR GAWVPAGSRE LVAHHPKLLL PPGYFPAGRY VVVAESPLPP GEWELCRAAP GPAYEEEGTP LRYQRLVPSR SRIVRTPSLK DSPAGRGLSK AAVSEELKWW HERARLRSTR PHSLDRQGAF RVRSLPLGRE GFGRALGPRA QVPTVCVLRR SPDGAPVQVF VPEKGEIISQ V (314-663 aa encoded by BC106877)
靶标信息
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Innate immunity activator protein; uncharacterized protein C1orf106 homolog
基因别名: 1700034M08Rik; 4933426C09Rik; AI586180; C1orf106; D1Mgi54; INAVA
UniProt ID: (Mouse) Q7TN12, (Human) Q3KP66
Entrez Gene ID: (Mouse) 67313, (Human) 55765, (Rat) 289399
