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Invitrogen
CACNA2D1 Monoclonal Antibody (20A)
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CACNA2D1 Antibody (MA3-921) in ICC/IF
Immunofluorescent analysis of Dihydropyridine Receptor alpha-2 in U251 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a Dihydropyridine Receptor alpha-2 monoclonal antibody (Product # MA3-921) at a dilution of 1:100 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). Dihydropyridine Receptor alpha-2 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown.... View More
产品信息
MA3-921
应用
建议稀释比
已发表文章
产品规格
种属反应
Guinea pig,
Human,
Mouse,
Rabbit,
Rat
已发表种属
C. elegans,
Fish,
Human,
Mouse,
Pig,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
20A
抗原
Purified rabbit dihydropyridine receptor.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-921 detects 1,4-dihydropyridine (DHP) receptor alpha-2 subunit from human, rat, mouse, guinea pig and rabbit skeletal and cardiac muscle.
MA3-921 has been successfully used in Western blot, immunocytochemistry, immunofluorescence, and immunohistochemistry procedures. By Western blot, this antibody detects a 220 kDa protein under non-reducing and a 143 kDa protein under reducing conditions representing DHP from rabbit skeletal muscle membrane preparations. Immunohistochemical staining of DHP in rabbit skeletal muscle with MA3-921 results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines.
The MA3-921 antigen is purified rabbit DHP receptor.
靶标信息
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type); calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; DHP; dihydropryridine-sensitive calcium channel alpha-2 subunit; dihydropyridine-sensitive calcium channel alpha 2; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; H_DJ0560O14.1; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1
基因别名: Ca(v)alpha2delta1; CACNA2; CACNA2D1; CACNL2A; CCHL2A; CCHLA2; DHSCCA; LINC01112; lncRNA-N3; MHS3
UniProt ID: (Rabbit) P13806, (Human) P54289, (Mouse) O08532
Entrez Gene ID: (Rabbit) 100009105, (Human) 781, (Rat) 25399, (Mouse) 12293
calcium ion transport
regulation of calcium ion transport
regulation of ventricular cardiac muscle cell membrane repolarization
calcium ion transport into cytosol
cardiac conduction
calcium ion transmembrane transport via high voltage-gated calcium channel
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of membrane repolarization during action potential
positive regulation of high voltage-gated calcium channel activity
regulation of ion transmembrane transport
calcium ion transmembrane transport
transport
ion transport
