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Invitrogen
CACNG2/4/8 Monoclonal Antibody (N245/36), PerCP
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CACNG2/4/8 Antibody (MA5-45586) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with TARP Gamma2/4/8 (Stargazin) monoclonal antibody (Product # MA5-45586) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-45586
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N245/36
抗原
Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
偶联物
PerCP
PerCP
PerCP
激发/发射光谱
482/675 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
1 µg/mL of MA5-45586 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 35-55kDa. Does not cross-react with TARPGamma3.
This antibody was formerly sold as clone S245-36.
靶标信息
Voltage-dependent calcium channel gamma-2 subunit, TARPGamma2 or Stargazin is encoded by the gene CACNG2 and is the transmembrane gamma subunit of the L-type calcium channel. Stargazin is in involved in regulation and trafficking of the ligand gated ion channel AMPA receptors. It is thought to play a role in learning and memory. Diseases associated with this gene include forms of deafness, Mental Retardation and childhood absnce epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CACNG2; calcium channel, voltage-dependent, gamma subunit 2; calcium channel, voltage-dependent, gamma subunit 4; calcium channel, voltage-dependent, gamma subunit 8; neuronal voltage-gated calcium channel gamma-2 subunit; neuronal voltage-gated calcium channel gamma-4 subunit; neuronal voltage-gated calcium channel gamma-8 subunit; regulatory subunit; stargazin; TARP gamma-2; TARP gamma-4; TARP gamma-8; transmembrane AMPAR regulatory protein gamma-2; transmembrane AMPAR regulatory protein gamma-4; transmembrane AMPAR regulatory protein gamma-8; unnamed protein product
基因别名: B230105C07Rik; B930041E13Rik; Ipr328; MRD10; stargazer; stargazin; stg; wag; waggler
UniProt ID: (Human) Q9Y698, (Human) Q9UBN1, (Human) Q8WXS5, (Mouse) O88602, (Rat) Q71RJ2, (Rat) Q8VHW9, (Mouse) Q9JJV4, (Rat) Q8VHW5
Entrez Gene ID: (Human) 10369, (Human) 27092, (Human) 59283, (Mouse) 12300, (Rat) 84347, (Rat) 140725, (Mouse) 54377, (Mouse) 81905, (Rat) 140729
protein targeting to membrane
calcium ion transport
transmission of nerve impulse
response to calcium ion
positive regulation of synaptic transmission, glutamatergic
eye blink reflex
calcium ion transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynaptic membrane neurotransmitter receptor levels
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein localization to basolateral plasma membrane
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to cocaine
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
neuromuscular junction development
regulation of membrane potential
neurological system process
membrane depolarization
membrane hyperpolarization
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