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CASK Polyclonal Antibody
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产品信息
600-401-AC1
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-CASK antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the N-terminus of human CASK.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium/calmodulin-dependent serine protein kinase; hCASK; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; RP23-278L4.1
基因别名: CASK; DXPri1; DXRib1; LIN-2; LIN2; mLin-2; Pals3
UniProt ID: (Rat) Q62915, (Mouse) O70589
Entrez Gene ID: (Rat) 29647, (Mouse) 12361
transcription coactivator activity
calmodulin-dependent protein kinase activity
G-protein coupled receptor activity
protein binding
calmodulin binding
ATP binding
protein C-terminus binding
PDZ domain binding
protein complex binding
neurexin family protein binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
scaffold/adaptor protein
negative regulation of cell-matrix adhesion
protein complex assembly
protein phosphorylation
intracellular protein transport
G-protein coupled receptor signaling pathway
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
phosphorylation
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