Invitrogen

CBP Polyclonal Antibody

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10 篇参考文献
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说明书
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问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
CBP Polyclonal Antibody

产品信息

PA5-27369

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

1:100-1:500
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染色质免疫沉淀 实验 (ChIP)

2.5 µg/10^6 cells
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产品规格

种属反应

Human, Mouse, Non-human primate

已发表种属

C. elegans, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the C-terminus region of human CBP. The exact sequence is proprietary.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.6 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2544845

产品详细信息

Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, HCT-116, Vero E6.

Predicted reactivity: Mouse (94%), Rat (94%), Rhesus Monkey (100%), Bovine (93%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CBP for CREB-binding protein is a 265 kDa nuclear protein which probably has many of the properties expected of a CREB co-activator. It shows substantial sequence homology with p300.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CREB-binding protein; Histone lysine acetyltransferase CREBBP; Protein lactyltransferas CREBBP; Protein-lysine acetyltransferase CREBBP

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基因别名: AW558298; CBP; CBP/p300; CREBBP; KAT3A; p300/CBP; RSTS

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UniProt ID: (Human) Q92793

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Entrez Gene ID: (Human) 1387, (Mouse) 12914

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功能
core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcriptional repressor activity, RNA polymerase II transcription factor binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding transcription factor binding zinc ion binding acetyltransferase activity peptide N-acetyltransferase activity peroxisome proliferator activated receptor binding MRF binding SMAD binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription cofactor activity transferase activity transferase activity, transferring acyl groups activating transcription factor binding metal ion binding histone modifying enzyme
参与通路
negative regulation of transcription from RNA polymerase II promoter response to hypoxia stimulatory C-type lectin receptor signaling pathway regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter protein complex assembly protein acetylation signal transduction Notch signaling pathway cell proliferation regulation of smoothened signaling pathway viral process histone acetylation N-terminal peptidyl-lysine acetylation positive regulation of type I interferon production cellular response to UV homeostatic process embryonic digit morphogenesis regulation of apoptotic process cellular lipid metabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process positive regulation of cell adhesion molecule production regulation of transcription from RNA polymerase II promoter in response to hypoxia response to interleukin-1 cell-cell adhesion regulation of cellular response to heat positive regulation of G1/S transition of mitotic cell cycle positive regulation of NIK/NF-kappaB signaling beta-catenin-TCF complex assembly transcription, DNA-templated transcription from RNA polymerase II promoter germ-line stem cell population maintenance positive regulation of sequence-specific DNA binding transcription factor activity
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