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Invitrogen
CCDC88C Polyclonal Antibody
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产品信息
PA5-52215
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SSLESSRNTS SNSSPLNLKG SSEQLHGRSE SFSSEDLIPS RDLATLPREA STPGRNALGR HEYPLPRNGP LPQEGAQKRG TAPPYVGVRP CSASPSSEMV TLEEFLEESN RSSPTHDTPS CRDDLLSD
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 79%.
靶标信息
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the disheveled protein and is a negative regulator of the Wnt signaling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the disheveled protein. Disheveled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; HkRP2; Hook-related protein 2; Protein Daple; spinocerebellar ataxia 40
基因别名: CCDC88C; DAPLE; HKRP2; KIAA1509; SCA40
UniProt ID: (Human) Q9P219
Entrez Gene ID: (Human) 440193
