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Proteintech
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Immunogen sequence: MSERKVLNK YYPPDFDPSK IPKLKLPKDR QYVVRLMAPF NMRCKTCGEY IYKGKKFNAR KETVQNEVYL GLPIFRFYIK CTRCLAEITF KTDPENTDYT MEHGATRNFQ AEKLLEEEEK RVQKEREDEE LNNPMKVLEN RTKDSKLEME VLENLQELKD LNQRQAHVDF EAMLRQHRLS EEERRRQQQE EDEQETAALL EEARKRRLLE DSDSEDEAAP SPLQPALRPN PTAILDEAPK PKRKVEVWEQ SVGSLGSRPP LSRLVVVKKA KADPDCSNGQ PQAAPTPGAP QNRKEANPTP LTPGASSLSQ LGAYLDSDDS NGSN (1-323 aa encoded by BC000561)
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coiled-coil domain-containing protein 94; Splicing factor YJU2
基因别名: 2900016D05Rik; AI413813; CCDC94; YJU2
UniProt ID: (Human) Q9BW85, (Mouse) Q9D6J3
Entrez Gene ID: (Human) 55702, (Rat) 501285, (Mouse) 72886