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Invitrogen
CD105 (Endoglin) Monoclonal Antibody (MEM-229), Biotin
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-28545
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
MEM-229
抗原
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
偶联物
Biotin
Biotin
Biotin
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD105 antigen; circulating isoform of endoglin TGF-beta receptor type III; endoglin precursor; ORW; soluble endoglin; unnamed protein product
基因别名: END; HHT1; ORW1
UniProt ID: (Pig) P37176, (Human) P17813
Entrez Gene ID: (Pig) 397096, (Human) 2022
type II transforming growth factor beta receptor binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
transmembrane signaling receptor activity
protein binding
galactose binding
coreceptor activity
receptor activator activity
BMP binding
identical protein binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transmembrane signal receptor
cell adhesion
transforming growth factor beta receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
vasculogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
heart looping
sprouting angiogenesis
positive regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
regulation of transcription, DNA-templated
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
regulation of cell adhesion
negative regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
dorsal aorta morphogenesis
wound healing
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
positive regulation of protein kinase B signaling
atrial cardiac muscle tissue morphogenesis
cell chemotaxis
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
detection of hypoxia
endocardial cushion to mesenchymal transition
vascular smooth muscle cell development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of vascular smooth muscle cell differentiation
atrioventricular canal morphogenesis
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of cell proliferation involved in heart morphogenesis
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