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Invitrogen
CD11a/CD18 (Rovelizumab Biosimilar) Recombinant Human Monoclonal Antibody
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CD11a/CD18 (Rovelizumab Biosimilar) Antibody (MA5-41889) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human ITGAL/CD11a/ITGB2/CD18 protein expressed in CHO cells using a CD11a/CD18 (Rovelizumab Biosimilar) monoclonal antibody (Product # MA5-41889). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-41889
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human ITGAL/CD11a/ITGB2/CD18
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.86 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
This product is a Humanized mouse antibody.
靶标信息
CD11/CD18 (LFA-1) are beta 2-type integrins. The leukocyte integrins are a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. T cells use integrins in essentially all of their functions. Integrins become active following signalling through other membrane receptors, which cause both affinity alteration and an increase in integrin clustering. The monoclonal antibody 24 recognizes a structural feature and is strictly dependent upon the presence of Mg2+. The epitope is located within, or in close proximity to, the three conserved cation binding domains and therefore a measure of Mg2+ bound to the leukocyte integrins and thus reflects functionally active molecules. The epitope can be induced on polymorphonuclear leukocytes and on monocytes. Glu173 and Glu175 of the beta(2) I domain are identified as critical for antibody 24 binding. The monoclonal antibody 24 inhibits monocyte-dependent, antigen specific T cell proliferation and IL-2- activated natural killer cell assays. The antibody does not interfere with mitogen-stimulated T cell proliferation. Furthermore the monoclonal antibody 24 prevents deadhesion of receptor/ligand pairs, possible locking leukocyte integrins in an active conformation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD11 antigen-like family member A; CD11a; CD18; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; Integrin alpha-L; Integrin beta-2; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1A
基因别名: CD11A; CD18; ITGAL; ITGB2; MFI7
Entrez Gene ID: (Human) 3683, (Human) 3689
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