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Invitrogen
CD123/CD16/NKp46 (Bexatamig Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562459
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ Ig Mix
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
IL-3Ra (interleukin-3 receptor alpha) is a member of the type I cytokine receptor family. It forms a heterodimer made of a unique alpha chain and a shared beta subunit (beta c/CD131). IL-3Ra transmits signals from interleukin-3 (IL-3). Binding of IL-3 promotes pairing of the alpha and beta chains, which is necessary for receptor activation, though not for high-affinity ligand binding. IL-3Ra is overexpressed on acute myeloid leukemia (AML) blasts compared with normal blood cells, making it a potential therapeutic target.
CD16, also called Fc gamma receptor III (FcgRIII), has two isoforms: FcgRIIIA (CD16A) and FcgRIIIB (CD16B), encoded by FCGR3A and FCGR3B on chromosome 1. FcgRIIIA is expressed on monocytes, macrophages, and natural killer (NK) cells, but not on T or B cells. It binds the Fc portion of IgG antibodies and helps clear immune complexes. When engaged, it triggers signaling pathways that promote antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release, and antigen presentation. FcgRIIIB is a GPI-anchored receptor found mainly on neutrophils and supports similar immune responses, including cytotoxicity and enhanced viral interactions. Mutations in FCGR3A are linked to Immunodeficiency 20, recurrent viral infections, systemic lupus erythematosus, alloimmune neonatal neutropenia, and herpes zoster. Multiple transcript variants exist.
CD335 (NKp46/NCR1) is a natural cytotoxicity receptor expressed on NK cells. It is a type I transmembrane glycoprotein with two immunoglobulin-like domains. CD335 activates and expands resting NK cells, particularly through interactions with dendritic cells, and enhances their ability to kill tumor and virus-infected cells, including influenza-infected cells. Related to LIR and KIR receptors, CD335 plays a key role in tumor cell lysis and has also been implicated in autoimmune processes such as type 1 diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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