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Invitrogen
CD137 (4-1BB) Monoclonal Antibody (4B4-1)
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CD137 (4-1BB) Antibody (MA5-28559) in Flow
Separation of cells stained using anti-humam CD137 (4B4-1) purified Monoclonal antibody (Product # MA5-28559) (low endotoxin, concentration in sample 4 µg/mL, GAM APC, red-filled) from cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral blood mononuclear cell suspension.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-28559
应用
建议稀释比
已发表文章
产品规格
种属反应
Baboon,
Chimpanzee,
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B4-1
抗原
Recombinant human CD137 ectodomain
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
Functional Application: Inhibition.
靶标信息
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); induced by lymphocyte activation; similar to Human receptor protein encoded by GenBank Accession Number U03397; interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB homolog; tumor necrosis factor receptor superfamily, member 9; unnamed protein product
基因别名: 4-1BB; CD137; CDw137; EGK_00183; ILA; IMD109
UniProt ID: (Human) Q07011
Entrez Gene ID: (Human) 3604, (Cynomolgus monkey) 102127961, (Rhesus monkey) 708281
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