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Invitrogen
CD154 (CD40 Ligand) Polyclonal Antibody
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CD154 (CD40 Ligand) Antibody (PA5-78984) in IHC (P)
Immunohistochemistry analysis of CD154 (CD40 Ligand) on paraffin-embedded human mammary cancer tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CD154 (CD40 Ligand) polyclonal antibody (Product# PA5-78984) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabb... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78984
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L (47-65aa HRRLDKIEDERNLHEDFVF).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell, HELA whole cell, JURKAT whole cell, HMY2 whole cell, COLO320 whole cell. IHC: rat intestine tissue, human mammary cancer tissue.
靶标信息
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD154; CD40 ligand; CD40 ligand CD154; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily, member 5; Tumor necrosis factor ligand superfamily member 5
基因别名: CD40L; CD40LG; TNFSF5; TRAP
UniProt ID: (Rat) Q9Z2V2
Entrez Gene ID: (Rat) 84349
positive regulation of immune response to tumor cell
inflammatory response
immune response
platelet activation
B cell differentiation
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
B cell proliferation
negative regulation of apoptotic process
isotype switching
positive regulation of MHC class II biosynthetic process
immunoglobulin secretion
regulation of immunoglobulin secretion
dendritic cell differentiation
positive regulation of endothelial cell apoptotic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
