Search
Invitrogen
CD16/CD32 Chimeric Recombinant Rabbit Monoclonal Antibody (2.4G2)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
MA5-47770
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2.4G2
抗原
Mouse BALB/c Macrophage J774 Cell Line.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: This antibody binds to an epitope on the extracellular domains of the mouse Fc-gamma-III and Fc-gamma-II, thereby inhibiting their ability to bind antibodies via their Fc region receptors. Also binding the Fc-gamma-I receptor (CD64) via its Fc domain.
This antibody binds murine Fc Receptors CD16/CD32 and inhibits binding of antibodies to these. It can therefore be used as an Fc-blocking reagent, to reduce non-specific staining of cells by antibodies binding via their Fc-region. This recombinant antibody has been engineered with point mutations that eliminate binding to Fc receptors, enabling reduction in background and superior signal to noise.
靶标信息
CD16 is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by natural killer (NK) cells, and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC (antibody dependent cell mediated cytotoxicity) by NK cells. IN comparison, CD32 is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII), and mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. Further, CD32 is involved in the phagocytosis of immune complexes, the regulation of antibody production by B-cells, and variations of the CD32 gene may increase vulnerability to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD16A; CD16B; CD32 receptor 2; CDw32; fc gamma receptor IIB; Fc gamma receptor III; Fc gamma receptor precursor; Fc gamma RIIB; fc-gamma RII; Fc-gamma RII-b; Fc-gamma RII-c; fc-gamma RIII; Fc-gamma-1/gamma-2bR receptor precursor; Fc-gamma-R-alpha receptor; Fc-gamma-R-beta-1 precursor; Fc-gamma-R-beta-2 precursor; Fc-gamma-RII; fc-gamma-RIIB; Fc-gamma-RIIc; Fcg receptor III; FCG2; FcgammaRIIB; FcgammaRIII; FCGR2C; FCGR3A; FCGR3B; FCGRIII; FCR-10; FcRII-b; FcRII-c; fcRIII; FCRIIIA; FGFR2B; igG Fc receptor II beta; igG Fc receptor III; low affinity immunoglobulin gamma Fc region receptor II; lymphocyte antigen 17; RP11-5K23.1; unnamed protein product
基因别名: CD16; CD32; F630109E10Rik; Fc[g]RII; Fcgr2; Fcgr2a; FcgRII; Fcr-2; Fcr-3; fcRII; Ly-17; Ly-m20; LyM-1
UniProt ID: (Mouse) P08101
Entrez Gene ID: (Mouse) 14130, (Mouse) 14131
antibody-dependent cellular cytotoxicity
negative regulation of type I hypersensitivity
immune complex clearance
negative regulation of immunoglobulin production
negative regulation of inflammatory response to antigenic stimulus
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of humoral immune response mediated by circulating immunoglobulin
receptor-mediated endocytosis
phagocytosis, engulfment
defense response
cell surface receptor signaling pathway
response to bacterium
immunoglobulin mediated immune response
dendrite development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cerebellum development
negative regulation of B cell proliferation
endocytic recycling
negative regulation of interleukin-10 production
positive regulation of tumor necrosis factor production
negative regulation of neutrophil apoptotic process
Fc-gamma receptor signaling pathway
positive regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
negative regulation of phagocytosis
positive regulation of phagocytosis
regulation of immune response
negative regulation of immune response
cellular response to molecule of bacterial origin
Fc receptor-mediated immune complex endocytosis
regulation of dendritic spine maintenance
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
cellular response to beta-amyloid
positive regulation of response to endoplasmic reticulum stress
positive regulation of type IIa hypersensitivity
positive regulation of type III hypersensitivity
positive regulation of type I hypersensitivity
serotonin secretion
phagocytosis, recognition
neutrophil chemotaxis
antigen processing and presentation of exogenous peptide antigen via MHC class I
mast cell activation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
