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Leinco Technologies
CD209b Monoclonal Antibody (22D1), Functional Grade, In Vivo GOLD™
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产品信息
C2859-1MG
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Armenian hamster
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
22D1
抗原
Purified Recombinant Mouse CD209b (C-terminal peptide)
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
no preservative
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Specificity: Clone 22D1 recognizes an epitope on mouse CD209b.
Endotoxin Level: ≤ 1.0 EU/mg as determined by the LAL method. Purity: >95% by SDS Page; ≥95% monomer by analytical SEC.
Product Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling: Functional grade preclinical antibodies may be stored sterile as received at 2-8 C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80 C. Avoid Repeated Freeze Thaw Cycles.
This antibody has been tested in the following applications: Western Blotting, Immunohistochemistry-Fresh Frozen, Flow Cytometry, Blocking.
靶标信息
SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; DC SIGNR1; DC-SIGN; DC-SIGN-related protein 1; DC-SIGNR1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; OtB7
基因别名: 1810030I22Rik; CD209; Cd209a; Cd209b; CDSIGN; CIRE; DC-SIGN; DC-SIGN1; DC-SIGNR1; Dcsign; mSIGNR1; OtB7; SIGN-R1; SIGNR1; SIGNR5
UniProt ID: (Mouse) Q91ZX1, (Mouse) Q8CJ91
Entrez Gene ID: (Mouse) 170786, (Mouse) 69165
endocytosis
regulation of gene expression
regulation of blood coagulation
regulation of T cell proliferation
viral entry into host cell
detection of yeast
phagocytosis, recognition
detection of bacterium
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of phagocytosis
