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Invitrogen
CD24 Monoclonal Antibody (YBM5.10.4), FITC
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产品信息
MA5-17894
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2c
分类
Monoclonal
类型
Antibody
克隆号
YBM5.10.4
抗原
Mouse monoclonal antibodies raised against mouse CD24.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17894 targets CD24/HSA in FACS applications and shows reactivity with Mouse samples.
The MA5-17894 immunogen is mouse monoclonal antibodies raised against mouse CD24.
靶标信息
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD24 is thought to play a role in regulating B-cell proliferation and maturation, as well as in controlling autoimmunity. Additionally, CD24 has been reported to interact with P-selectin (CD62P), indicating a potential role in cell adhesion and signaling. CD24 is a valuable marker for studying B-cell development, leukemia, lymphoma, and autoimmune regulation, as well as its interactions with other molecules like P-selectin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD24; cluster of differentiation 24; FLJ22950; FLJ43543; heat stable antigen; HSA; Ly-52; Lymphocyte antigen 52; M1/69-J11D heat stable antigen; MGC75043; Nectadrin; R13-Ag; Signal transducer CD24; X62 heat stable antigen
基因别名: Cd24; Cd24a; HSA; Ly-52; nectadrin
UniProt ID: (Mouse) P24807
Entrez Gene ID: (Mouse) 12484
response to hypoxia
cell activation
regulation of cytokine-mediated signaling pathway
response to molecule of bacterial origin
pre-B cell differentiation
leukocyte migration involved in inflammatory response
positive regulation of T cell mediated immune response to tumor cell
positive regulation of inflammatory response to antigenic stimulus
positive regulation of B cell apoptotic process
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuromuscular synaptic transmission
negative regulation of neuroblast proliferation
apoptotic mitochondrial changes
positive regulation of neuron projection development
cell migration
regulation of cell-cell adhesion
positive regulation of cell-cell adhesion
apoptotic nuclear changes
negative regulation of B cell proliferation
neuron projection development
T cell costimulation
chemokine receptor transport out of membrane raft
negative regulation of transforming growth factor beta3 production
positive regulation of integrin activation
positive regulation of cell adhesion mediated by integrin
regulation of cell-cell adhesion mediated by integrin
positive regulation of cell-cell adhesion mediated by integrin
negative regulation of erythrocyte clearance
homotypic cell-cell adhesion
negative regulation of erythrocyte aggregation
positive regulation of T cell homeostatic proliferation
positive regulation of activated T cell proliferation
regulation of phosphorylation
cholesterol homeostasis
positive regulation of MAP kinase activity
regulation of MAPK cascade
response to estrogen
regulation of B cell differentiation
negative regulation of neuron differentiation
respiratory burst
negative regulation of T cell homeostatic proliferation
positive regulation of alpha-beta T cell proliferation
synaptic vesicle endocytosis
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
positive regulation of calcium-mediated signaling
positive regulation of protein tyrosine kinase activity
apoptotic signaling pathway
