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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
This antibody recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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蛋白别名: FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; fibroblast growth factor-regulated protein 2; tweak-receptor; type I transmembrane protein Fn14; unnamed protein product
基因别名: CD266; FN14; HPIP; TWEAK-R; TWEAKR
UniProt ID: (Human) Q9NP84, (Mouse) Q9CR75
Entrez Gene ID: (Human) 51330, (Mouse) 27279