Invitrogen

CD3/CD44 Antibody Cocktail, FITC, PE

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
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产品信息

MA1-12273

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Cocktail

类型

Antibody

克隆号

M2AB, 7F1

抗原

human thymocytes and TCR-gamma epsilon thymocytes

偶联物

FITC , PE FITC , PE FITC , PE

形式

Liquid

纯化类型

Protein A/G

保存液

PBS with 0.2% carrier protein

内含物

0.08% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1072009

产品详细信息

This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD44 (clone 7F1, isotype IgG1).

靶标信息

CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; FLJ18683; GP90 lymphocyte homing/adhesion receptor; HCAM; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; OKT3, delta chain; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD44; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain

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基因别名: CD3-DELTA; CD3-GAMMA; CD3D; CD3E; CD3G; CD44; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IMD17; IMD18; IMD19; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) P16070

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 960

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功能
transcription coactivator activity transmembrane signaling receptor activity protein heterodimerization activity receptor signaling protein activity protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding cytokine receptor activity collagen binding hyaluronic acid binding transmembrane signal receptor
参与通路
cell surface receptor signaling pathway T cell differentiation T cell costimulation positive thymic T cell selection positive regulation of transcription from RNA polymerase II promoter regulation of immune response T cell receptor signaling pathway positive regulation of T cell anergy protein complex assembly transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway response to nutrient positive regulation of gene expression negative regulation of gene expression positive regulation of interferon-gamma production positive regulation of interleukin-4 production positive regulation of T cell proliferation T cell activation regulation of apoptotic process negative thymic T cell selection positive regulation of interleukin-2 biosynthetic process negative regulation of smoothened signaling pathway positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling apoptotic signaling pathway establishment or maintenance of cell polarity protein transport Fc-gamma receptor signaling pathway involved in phagocytosis regulation of lymphocyte apoptotic process cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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