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Proteintech
CD31 Recombinant Rabbit Monoclonal Antibody (4N13), CoraLite® 594
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产品信息
CL594-80530
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4N13
抗原
CD31 fusion protein Ag1787
偶联物
激发/发射光谱
593/614 nm
形式
Liquid
浓度
1000 µg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: EVRCESISGT LPISYQLLKT SKVLENSTKN SNDPAVFKDN PTEDVEYQCV ADNCHSHAKM LSEVLRVKVI APVDEVQISI LSSKVVESGE DIVLQCAVNE GSGPITYKFY REKEGKPFYQ MTSNATQAFW TKQKANKEQE GEYYCTAFNR ANHASSVPRS KILTVRVILA PWKKGLIAVV IIGVIIALLI IAAKCYFLRK AKAKQMPVEM SRPAVPLLNS NNEKMSDPNM EANSHYGHND DVGNHAMKPI NDNKEPLNSD VQYTEVQVSS AESHKDLGKK DTETVYSEVR KAVPDAVESR YSRTEGSLDG T
靶标信息
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD31; CD31 antigen; EndoCAM; GPIIA'; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
基因别名: C85791; CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; Pecam; PECAM-1; PECAM1
UniProt ID: (Human) P16284, (Mouse) Q08481
Entrez Gene ID: (Human) 5175, (Mouse) 18613
