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Invitrogen
CD31 (PECAM-1) Polyclonal Antibody
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CD31 (PECAM-1) Antibody (PA5-79805) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CD31 (PECAM-1) in paraffin-embedded section of mouse epididymis tissue using CD31 (PECAM-1) Polyclonal Antibody (Product # PA5-79805). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dil... View More
产品信息
PA5-79805
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse CD31 recombinant protein (Position: R58-Q273).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse lung tissue. IHC: mouse colon tissue, mouse colon tissue, mouse colon tissue, mouse epididymis tissue, mouse heart tissue, mouse liver tissue, mouse pancrease tissue, mouse stomach tissue, mouse thymus tissue.
靶标信息
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD31; PECAM-1; Platelet endothelial cell adhesion molecule
基因别名: C85791; Cd31; Pecam; PECAM-1; Pecam1
UniProt ID: (Mouse) Q08481
Entrez Gene ID: (Mouse) 18613
