Leinco Technologies

CD317 Monoclonal Antibody (927), Functional Grade, In Vivo GOLD™

Name: CD317 Monoclonal Antibody (927), Functional Grade, In Vivo GOLD\u2122
Brand: Leinco Technologies
SKU: C791-100MG

查看其他50个BST-2 (CD317)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image CD317 Monoclonal Antibody (927), Functional Grade, In Vivo GOLD™

产品信息

C791-100MG

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

流式细胞分析 (Flow)

Assay-dependent

功能检测 (Functional)

Assay-dependent

免疫电镜技术 (IM)

Assay-dependent

抑制试剂 (Inhibition)

Assay-dependent

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

927

抗原

Mouse plasmacytoid dendritic cells

查看免疫原

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

≥5.0 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.2-7.4

内含物

no preservative

保存条件

4°C short term, -80°C long term

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Specificity: Clone 927 activity is directed against murine CD317 (BST2; PDCA-1).

Endotoxin Level: <0.1 EU/µg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -70C. Avoid Repeated Freeze Thaw Cycles.

靶标信息

BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。