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CD357 (AITR/GITR) Recombinant Mouse Monoclonal Antibody (eBioAITR), Alexa Fluor™ Plus 488
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CD357 (AITR/GITR) Antibody (740198MP488) in Flow
Flow cytometry analysis of CD357 (AITR/GITR) Recombinant Mouse Monoclonal Antibody (eBioAITR), Alexa Fluor™ Plus 488 (Product # 740198MP488) was performed using RPMI 8226 and Jurkat cells. Cells were stained with 0.125 µg of CD357 (AITR/GITR) Recombinant Mouse Monoclonal Antibody (eBioAITR), Alexa Fluor™ Plus 488 (Product # 740198MP488). CD357 higher expression was observed in RPMI 8226 (pink histogram) in ... View More
产品信息
740198MP488
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
eBioAITR
偶联物
Alexa Fluor™ Plus 488
Alexa Fluor™ Plus 488
Alexa Fluor™ Plus 488
激发/发射光谱
493/518 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Protein A/G
保存液
proprietary buffer, pH 6.3-7.3
内含物
0.008% Bromonitrodioxane, 0.008% Methylisothiazolone
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Wet ice
产品详细信息
Alexa Fluor™ Plus recombinant antibodies are conjugated using new, proprietary dye chemistry so you can generate stunning data. Alexa Fluor™ Plus antibodies represent an advancement in fluorescent conjugate technology. Alexa Fluor™ Plus antibodies provide brighter signal compared to leading Alexa Fluor™ antibodies, providing you with better signal-to-noise for your critical experiments. These antibodies show better specificity and lot-to-lot consistency as these are recombinant antibodies, generated by cloning specific genes for the desired antibodies into an expression vector and expressed in vitro.
Using conjugate solutions: Centrifuge the protein conjugate solution briefly in a microcentrifuge before use; add only the supernatant to the experiment. This step will help eliminate any protein aggregates that may have formed during storage, thereby reducing nonspecific background staining.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 494 nm; Emission: 519 nm; Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activation-inducible TNFR family receptor; AITR; CD357; GITR; TNF receptor homolog; similar to murine glucocorticoid-induced TNFR-related protein; Glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; Tumor necrosis factor receptor superfamily member 18; UNQ319; variant (4) contains an extra coding segment, which leads to a frame shift, compared to variant 1 and 3; resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different
基因别名: AITR; CD357; ENERGEN; GITR; GITR-D; TNFRSF18; UNQ319/PRO364
UniProt ID: (Human) Q9Y5U5
Entrez Gene ID: (Human) 8784
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