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Invitrogen
CD4 Monoclonal Antibody (CC8)
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CD4 Antibody (MA5-28361) in Flow
Flow cytometry of CD4 in red cell lysed bovine blood. Sample was incubated with CD4 monoclonal antibody (Product # MA5-28361) and gated on lymphocytes. Figures are arranged as follows: A) FITC conjugated mouse anti bovine CD2 and Alexa Fluor 647 conjugated mouse IgG2a isotype control. B) FITC conjugated mouse anti bovine CD2 and Alexa Fluor 647 conjugated mouse anti bovine CD4.
产品信息
MA5-28361
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
CC8
抗原
Bovine lymphocytes
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes bovine CD4, the homolog of human CD4 and immunoprecipitates approximately a 50 kDa molecule. The phenotype, tissue distribution and function of T-cells expressing the bovine CD4 antigen are similar to those in other species. However, expression on macrophages has not yet been detected.
靶标信息
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD4 antigen; CD4 antigen p55; cd4a; fCD4; Leu-3
Entrez Gene ID: (Bovine) 407098
