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Invitrogen
CD51 (Integrin alpha V) Monoclonal Antibody (RMV-7)
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产品信息
MA5-28175
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
RMV-7
抗原
Cultured LAK cells from Balb/c mice
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes murine CD51, approximately a 140 kDa alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61.
靶标信息
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha v integrin; CD51; CD61; GP3A; GPIIIa; Integrin alpha-V; ITGB3; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha; VNR
基因别名: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; Itgav
UniProt ID: (Mouse) P43406
Entrez Gene ID: (Mouse) 16410
opsonin binding
fibronectin binding
protease binding
protein kinase C binding
receptor binding
voltage-gated calcium channel activity
insulin-like growth factor I binding
peptide binding
metal ion binding
protein heterodimerization activity
extracellular matrix binding
extracellular matrix protein binding
integrin
angiogenesis
blood vessel development
cellular calcium ion homeostasis
inflammatory response
cell adhesion
cell-matrix adhesion
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
multicellular organism development
positive regulation of cell proliferation
fertilization
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
cell growth
cell migration
cell differentiation
positive regulation of cell migration
cell-substrate adhesion
negative regulation of lipid transport
detection of molecule of bacterial origin
positive regulation of osteoblast proliferation
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
regulation of ion transmembrane transport
gonad morphogenesis
endodermal cell differentiation
apolipoprotein A-I-mediated signaling pathway
T cell activation
apoptotic cell clearance
positive regulation of MAPK cascade
endothelial cell migration
regulation of bone resorption
negative regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of cell adhesion
viral entry into host cell
focal adhesion assembly
negative regulation of lipoprotein metabolic process
regulation of phagocytosis
negative chemotaxis
release of sequestered calcium ion into cytosol
trophoblast giant cell differentiation
ERK1 and ERK2 cascade
calcium ion transmembrane transport
response to nitric oxide
extrinsic apoptotic signaling pathway in absence of ligand
regulation of apoptotic cell clearance
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
