Invitrogen

CD63 Monoclonal Antibody (AD1), FITC

Name: CD63 Monoclonal Antibody (AD1), FITC
Brand: Invitrogen
SKU: MA5-41031

查看其他95个CD63抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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CD63 Antibody (MA5-41031) in Flow

Flow Cytometry of CD63 in rat peripheral blood platelets. Samples were incubated with CD63 monoclonal antibody (Product # MA5-41031) followed by Alexa Fluor 488.

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Immunogen image

Immunogen Image CD63 Monoclonal Antibody (AD1), FITC

产品信息

MA5-41031

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Neat

产品规格

种属反应

Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

AD1

抗原

RBL-2H3 rat basophilic leukaemia cell line.

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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein A

保存液

PBS with 1% BSA

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

运输条件

Ambient (domestic); Wet ice (international)

AB_2898786

靶标信息

CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。