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Invitrogen
CD98 Polyclonal Antibody
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产品信息
PA1-85012
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide: N terminal region of CD98 light chain
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C or -20°C if preferred
运输条件
Wet ice
RRID
产品详细信息
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is placenta. In Western blot, this antibody detects a band at ~50-55kDa in human liver cell lysate.
Rabbit anti Human CD98 light chain antibody detects an epitope within the N-terminal (NT) region of the CD98 light chain (CD98LC), also known as the 4F2 light chain, or LAT-1.
靶标信息
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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