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Abnova
CDK2 Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01286
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to human Cdk2.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; Cell division protein kinase 2; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase
Gene Aliases: CDK2; CDKN2; p33(CDK2)
UniProt ID: (Human) P24941
Entrez Gene ID: (Human) 1017
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
lens development in camera-type eye
DNA replication
DNA repair
potassium ion transport
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
centriole replication
meiotic nuclear division
Ras protein signal transduction
positive regulation of cell proliferation
response to toxic substance
histone phosphorylation
peptidyl-serine phosphorylation
organ regeneration
mitotic G1 DNA damage checkpoint
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
response to drug
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
centrosome duplication
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
response to cAMP
response to electrical stimulus
regulation of gene silencing
cellular response to nitric oxide
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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