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Invitrogen
CDK7 Polyclonal Antibody
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CDK7 Antibody (PA1-29162) in ChIP
Chromatin immunoprecipitation analysis of Cdk7 was performed using cross-linked chromatin from 1 x 106 HCT116 colon carcinoma cells treated with serum for 0, 15, 30, and 60 minutes. Immunoprecipitation was performed using a multiplex microplate Matrix ChIP assay (see reference for Matrix ChIP protocol: http://www.ncbi.nlm.nih.gov/pubmed/22098709) with 1.0ul/100ul well volume of a Cdk7 polyclonal antibody (Product # PA1-29162). Chromatin aliquots from ~1 x 105 cells were used per ChIP pull-down. Quantitative PCR data were done in quadruplic... View More
产品信息
PA1-29162
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from the C-terminus of human Cdk7 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-29162 detects CDK7 from human samples.
PA1-29162 has been successfully used in ChIP, immunoprecipitation, Western blot applications.
The PA1-29162 immunogen is: Synthetic peptide derived from the C-terminus of human Cdk7 protein.
靶标信息
The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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