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Proteintech
CDT1 Polyclonal Antibody
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产品信息
14382-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CDT1 Fusion Protein Ag5810 (195-546 aa encoded by BC000137)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EMFRSMDTI VGMLHNRSET PTFAKVQRGV QDMMRRRFEE RNVGQIKTVY PASYRFRQER SVPTFKDGTR RSDYQLTIEP LLEQEADGAA PQLTASRLLQ RRQIFSQKLV EHVKEHHKAF LASLSPAMVV PEDQLTRWHP RFNVDEVPDI EPAALPQPPA TEKLTTAQEV LARARNLISP RMEKALSQLA LRSAAPSSPG SPRPALPATP PATPPAASPS ALKGVSQDLL ERIRAKEAQK QLAQMTRCPE QEQRLQRLER LPELARVLRS VFVSERKPAL SMEVACARMV GSCCTIMSPG EMEKHLLLLS ELLPDWLSLH RIRTDTYVKL DKAADLAHIT ARLAHQTRAE EGL (195-546 aa encoded by BC000137)
靶标信息
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CDT1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP
基因别名: CDT1; DUP; RIS2
UniProt ID: (Human) Q9H211
Entrez Gene ID: (Human) 81620
