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Invitrogen
CETP Polyclonal Antibody
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CETP Antibody (PA5-89297) in IHC (P)
Immunohistochemistry analysis of CETP in paraffin-embedded human stomach. Samples were incubated with CETP Polyclonal antibody (Product # PA5-89297). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. 40x lens.
产品信息
PA5-89297
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-493 of human CETP (NP_0000692)
偶联物
形式
Liquid
浓度
1.07 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LMLSLMGDEF KAVLETWGFN TNQEIFQEVV GGFPSQAQVT VHCLKMPKIS CQNKGVVVNS SVMVKFLFPR PDQQHSVAYT FEEDIVTTVQ ASYSKKKLFL SLLDFQITPK TVSNLTESSS ESVQSFLQSM ITAVGIPEVM SRLEVVFTAL MNSKGVSLFD IINPEIITRD GFLLLQMDFG FPEHLLVDFL QSLS; Positive Samples: A-549, HepG2, A375, Mouse liver, Rat liver; Cellular Location: extracellular space
靶标信息
It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BPI fold containing family F; Cholesteryl ester transfer protein; cholesteryl ester transfer protein plasma; cholesteryl ester transfer protein, plasma; Lipid transfer protein I
基因别名: BPIFF; CETP; HDLCQ10
UniProt ID: (Human) P11597
Entrez Gene ID: (Human) 1071
triglyceride metabolic process
lipid transport
receptor-mediated endocytosis
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol efflux
phospholipid transport
cholesterol transport
triglyceride transport
very-low-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
phosphatidylcholine metabolic process
lipid homeostasis
phospholipid homeostasis
triglyceride homeostasis
