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Proteintech
CHI3L1 Polyclonal Antibody
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产品信息
12036-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHI3L1 Fusion Protein Ag2710 (34-383 aa encoded by BC008568)
偶联物
形式
Liquid
浓度
0.17 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: YREGDGSCF PDALDRFLCT HIIYSFANIS NDHIDTWEWN DVTLYGMLNT LKNRNPNLKT LLSVGGWNFG SQRFSKIASN TQSRRTFIKS VPPFLRTHGF DGLDLAWLYP GRRDKQHFTT LIKEMKAEFI KEAQPGKKQL LLSAALSAGK VTIDSSYDIA KISQHLDFIS IMTYDFHGAW RGTTGHHSPL FRGQEDASPD RFSNTDYAVG YMLRLGAPAS KLVMGIPTFG RSFTLASSET GVGAPISGPG IPGRFTKEAG TLAYYEICDF LRGATVHRIL GQQVPYATKG NQWVGYDDQE SVKSKVQYLK DRQLAGAMVW ALDLDDFQGS FCGQDLRFPL TNAIKDALAA T (34-383 aa encoded by BC008568)
靶标信息
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 39 kDa synovial protein; Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39; YKL-40
基因别名: ASRT7; AW208766; Brp39; CGP-39; CHI3L1; Chil1; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40
UniProt ID: (Human) P36222, (Mouse) Q61362
Entrez Gene ID: (Human) 1116, (Mouse) 12654
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
activation of NF-kappaB-inducing kinase activity
response to mechanical stimulus
positive regulation of peptidyl-threonine phosphorylation
lung development
response to tumor necrosis factor
positive regulation of angiogenesis
cartilage development
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
response to interleukin-6
cellular response to interleukin-1
cellular response to tumor necrosis factor
interleukin-8 secretion
