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Invitrogen
CHRNA7 Recombinant Rabbit Monoclonal Antibody (PSH19-20)
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图: 1 / 13
CHRNA7 Antibody (MA571395) in ICC/IF
Immunofluorescence analysis of CHRNA7 using Jurkat. The cells were fixed in 4% paraformaldehyde for 15 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 15 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. The cells were co-labeled with CHRNA7 Recombinant Rabbit Monoclonal Antibody (PSH19-20) (Product # MA571395) (green) at 1:500 dilution and beta tubulin (red) in 1% BSA in PBST overnight at 4 degrees Celsius and then with iFluor™ 488 Goat Anti-Rabbit... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA571395
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH19-20
抗原
Recombinant protein within human CHRNA7 aa 290-502.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.2% ProClin 950
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: Jurkat cell lysate, HeLa cell lysate, A431 cell lysate, Caco-2 cell lysate, RAW264.7 cell lysate, C6 cell lysate, PC-12 cell lysate, Mouse brain tissue lysate, Mouse spleen tissue lysate, Rat brain tissue lysate, Rat spleen tissue lysate, mouse dorsal root ganglion tissue, rat dorsal root ganglion tissue, Jurkat, PC-12.
Tissue Specificity: Tissue enhanced (adrenal gland, intestine).
Subcellular Location: Postsynaptic cell membrane, cell membrane.
Sequence Similarities: 91% Mouse/Rat
Predicted band size: 56 kDa.
靶标信息
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a7 nicotinic acetylcholine receptor; acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha 7 neuronal nicotinic acetylcholine receptor; alpha 7-2; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; cytotransmitter gated ion channel; D-10; nAChR alpha7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal nicotinic acetycholine receptor alpha 7; neurotransmitter receptor; acra7; nicotinic acetylcholine receptor subunit alpha-7; nicotinic receptor alpha 7 subunit; unnamed protein product
基因别名: a7nAChR; Acra7; alpha7; BTX; CHRNA7-2; nAchR; nAChR7; NACHRA7; NARAD
UniProt ID: (Human) P36544, (Mouse) P49582, (Rat) Q05941
Entrez Gene ID: (Human) 1139, (Mouse) 11441, (Rat) 25302
beta-amyloid binding
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
calcium channel activity
protein binding
acetylcholine receptor activity
toxic substance binding
chloride channel regulator activity
acetylcholine-gated cation channel activity
neurotransmitter receptor activity
acetylcholine binding
protein homodimerization activity
adenylate cyclase binding
protein kinase binding
ATPase binding
scaffold protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
response to hypoxia
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
ion transport
cation transport
calcium ion transport
cellular calcium ion homeostasis
endocytosis
signal transduction
chemical synaptic transmission
synaptic transmission, cholinergic
learning or memory
memory
positive regulation of cell proliferation
associative learning
response to cold
positive regulation of gene expression
regulation of norepinephrine secretion
neuronal action potential
sperm motility
response to food
regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
ion transmembrane transport
response to nicotine
behavioral response to nicotine
T cell activation
B cell activation
regulation of membrane potential
ovulation cycle
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
response to ethanol
positive regulation of angiogenesis
behavioral response to ethanol
regulation of inflammatory response
negative regulation of inflammatory response
modulation of synaptic transmission
synapse organization
cognition
sensory processing
positive regulation of protein metabolic process
regulation of synapse structural plasticity
membrane depolarization
excitatory postsynaptic potential
synaptic transmission involved in micturition
generation of ovulation cycle rhythm
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
acetylcholine receptor signaling pathway
dendritic spine organization
modulation of excitatory postsynaptic potential
presynaptic modulation of chemical synaptic transmission
dendrite arborization
negative regulation of cytokine production involved in inflammatory response
positive regulation of long-term synaptic potentiation
positive regulation of beta-amyloid formation
negative regulation of beta-amyloid formation
negative regulation of intracellular signal transduction
regulation of amyloid precursor protein catabolic process
response to amyloid-beta
response to acetylcholine
regulation of amyloid fibril formation
activation of protein kinase C activity
ligand-gated ion channel signaling pathway
positive regulation of excitatory postsynaptic potential
regulation of response to drug
cell communication
short-term memory
signaling
calcium ion transmembrane transport
regulation of nitric oxide metabolic process
response to carbamate
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