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Proteintech
CIDEA Polyclonal Antibody
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产品信息
13170-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CIDEA Fusion Protein Ag3824 (1-253 aa encoded by BC031896)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The MW of this protein is 25 kDa, and this antibody specifically recognizes the 25 kDa protein.
Immunogen sequence: MRGDRASGG PGNHNGSWAR EGPRLGPSWK RGLWSPRGGP NRPAEPSRPL TFMGSQTKRV LFTPLMHPAR PFRVSNHDRS SRRGVMASSL QELISKTLDA LVIATGLVTL VLEEDGTVVD TEEFFQTLGD NTHFMILEKG QKWMPGSQHV PTCSPPKRSG IARVTFDLYR LNPKDFIGCL NVKATMYEMY SVSYDIRCTG LKGLLRSLLR FLSYSAQVTG QFLIYLGTYM LRVLDDKEER PSLRSQAKGR FTCG (1-253 aa encoded by BC031896)
靶标信息
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; cell death-inducing DNA fragmentation factor, alpha subunit-like effector A; cide a; Lipid transferase CIDEA
基因别名: AW212747; CIDE-A; CIDEA
UniProt ID: (Human) O60543, (Mouse) O70302
Entrez Gene ID: (Human) 1149, (Mouse) 12683, (Rat) 291541
temperature homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
lipid metabolic process
apoptotic process
cell death
positive regulation of sequestering of triglyceride
lipid storage
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of tumor necrosis factor production
response to stilbenoid
regulation of apoptotic process
negative regulation of cytokine secretion
negative regulation of lipid catabolic process
negative regulation of execution phase of apoptosis
regulation of apoptotic DNA fragmentation
biological_process
