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Invitrogen
CIITA Polyclonal Antibody
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CIITA Antibody (PA5-79047) in IHC (P)
Immunohistochemistry analysis of CIITA on paraffin-embedded human intestinal cancer tissue. Sample was incubated with CIITA polyclonal antibody (Product# PA5-79047) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) with DAB chromogen method.
产品信息
PA5-79047
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human CIITA recombinant protein (Position: E945-R1130).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat thymus tissue, mouse thymus tissue, MCF-7 whole cell. IHC: mouse spleen tissue, rat spleen tissue, human intestinal cancer tissue.
靶标信息
CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIITA; class II transactivator; MH NLRA; MHC class II transactivator; MHC class II transactivator type I; MHC class II transactivator type III; MHC class II transactivator type IV; NLR family, acid domain containing; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
基因别名: C2TA; CIITA; CIITAIV; EG669998; Gm9475; MHC2TA; NLRA
UniProt ID: (Human) P33076, (Mouse) P79621
Entrez Gene ID: (Human) 4261, (Mouse) 12265, (Rat) 85483
DNA binding
transcription coactivator activity
protein binding
ATP binding
GTP binding
protein C-terminus binding
kinase activity
transferase activity, transferring acyl groups
protein complex binding
activating transcription factor binding
transcription regulatory region DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
immune response
phosphorylation
negative regulation of collagen biosynthetic process
response to interferon-gamma
positive regulation of MHC class I biosynthetic process
positive regulation of MHC class II biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
interferon-gamma-mediated signaling pathway
inflammatory response
aging
cellular response to electrical stimulus
cellular response to interferon-gamma
cellular response to exogenous dsRNA
