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Proteintech
CKAP4 Polyclonal Antibody
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产品信息
16686-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CKAP4 Fusion Protein Ag10019 (254-602 aa encoded by BC082972)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: IFTEVQKRS QKEINDMKAK VASLEESEGN KQDLKALKEA VKEIQTSAKS REWDMEALRS TLQTMESDIY TEVRELVSLK QEQQAFKEAA DTERLALQAL TEKLLRSEES VSRLPEEIRR LEEELRQLKS DSHGPKEDGG FRHSEAFEAL QQKSQGLDSR LQHVEDGVLS MQVASARQTE SLESLLSKSQ EHEQRLAALQ GRLEGLGSSE ADQDGLASTV RSLGETQLVL YGDVEELKRS VGELPSTVES LQKVQEQVHT LLSQDQAQAA RLPPQDFLDR LSSLDNLKAS VSQVEADLKM LRTAVDSLVA YSVKIETNEN NLESAKGLLD DLRNDLDRLF VKVEKIHEKV (254-602 aa encoded by BC082972)
靶标信息
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 63 kDa membrane protein; 63-kDa cytoskeleton-linking membrane protein; Climp-63; Cytoskeleton-associated protein 4; transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment; type-II transmembrane protein p63
基因别名: 5630400A09Rik; CKAP4; CLIMP-63; ERGIC-63; P63
UniProt ID: (Human) Q07065, (Mouse) Q8BMK4
Entrez Gene ID: (Human) 10970, (Mouse) 216197, (Rat) 362859
