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Abnova
CLASP2 Monoclonal Antibody (3E9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00023122-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E9
抗原
CLASP2 (AAH29035.1, 1 a.a. approximately 431 a.a) full-length recombinant protein with GST-pstS1 tag.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.38 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MRRLICKRIC DYKSFDDEES VDGNRPSSAA SAFKVPAPKT SGNPANSARK PGSAGGPKVG GASKEGGAGA VDEDDFIKAF TDVPSIQIYS SRELEETLNK IREILSDDKH DWDQRANALK KIRSLLVAGA AQYDCFFQHL RLLDGALKLS AKDLRSQVVR EACITVAHLS TVLGNKFDHG AEAIVPTLFN LVPNSAKVMA TSGCAAIRFI IRHTHVPRLI PLITSNCTSK SVPVRRRSFE FLDLLLQEWQ THSLERHAAV LVETIKKGIH DADAEARVEA RKTYMGLRNH FPGEAETLYN SLEPSYQKSL QTYLKSSGSV ASLPQSDRSS SSSQESLNRP FSSKWSTANP STVAGRVSAG SSKASSLPGS LQRSRSDIDV NAAAGAKAHH AAGQSVRSGR LGAGALNAGS YASLECEAFW RSGRTAKLYS V
靶标信息
CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CLASP2-delta; CLASP2-epsilon; CLIP-associating protein CLASP2; multiple asters (Mast)-like homolog 2; protein Orbit homolog 2; unnamed protein product
UniProt ID: (Human) O75122
Entrez Gene ID: (Human) 23122
microtubule cytoskeleton organization
microtubule nucleation
negative regulation of microtubule depolymerization
Golgi organization
mitotic spindle organization
establishment or maintenance of cell polarity
exit from mitosis
positive regulation of epithelial cell migration
vesicle-mediated transport
regulation of axon extension
microtubule organizing center organization
regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
regulation of microtubule-based process
regulation of actin cytoskeleton organization
microtubule anchoring
platelet-derived growth factor receptor-beta signaling pathway
establishment of mitotic spindle localization
positive regulation of exocytosis
negative regulation of stress fiber assembly
regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
basement membrane organization
positive regulation of extracellular matrix disassembly
mitotic spindle assembly
presynaptic cytoskeleton organization
negative regulation of wound healing, spreading of epidermal cells
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