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Proteintech
CLOCK Polyclonal Antibody
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产品信息
18094-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CLOCK Fusion Protein Ag12826 (1-351 aa encoded by BC041878)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MLFTVSCSK MSSIVDRDDS SIFDGLVEED DKDKAKRVSR NKSEKKRRDQ FNVLIKELGS MLPGNARKMD KSTVLQKSID FLRKHKEITA QSDASEIRQD WKPTFISNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR GTIDPKEPST YEYVKFIGNF KSLNSVSSSA HNGFEGTIQR THRPSYEDRV CFVATVRLAT PQFIKEMCTV EEPNEEFTSR HSLEWKFLFL DHRAPPIIGY LPFEVLGTSG YDYYHVDDLE NLAKCHEHLM QYGKGKSCYY RFLTKGQQWI WL (1-351 aa encoded by BC041878)
靶标信息
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHe8; circadian locomoter output cycles kaput protein; Circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock homolog; hCLOCK
基因别名: BHLHE8; CLOCK; KAT13D; KIAA0334
UniProt ID: (Human) O15516
Entrez Gene ID: (Human) 9575
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
protein binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
DNA damage checkpoint
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
signal transduction
spermatogenesis
circadian rhythm
photoperiodism
entrainment of circadian clock
histone acetylation
circadian regulation of gene expression
regulation of hair cycle
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
regulation of insulin secretion
positive regulation of NF-kappaB transcription factor activity
response to redox state
cellular response to ionizing radiation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
