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Invitrogen
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PA1-521 detects CLOCK from cells transfected with the mouse CLOCK gene.
PA1-521 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects an ~100 kDa protein representing CLOCK from cells transfected with the mouse CLOCK gene.
The PA1-521 immunogen is a synthetic peptide corresponding to residues C S(394) L P E T A A D K S Q D S G S D N (410) of mouse CLOCK. This sequence is completely conserved between mouse and human CLOCK. PA1-521 immunizing peptide (Cat. # PEP-073) is available for use in neutralization and control experiments.
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。