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Proteintech
CLSTN1 Polyclonal Antibody
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产品信息
12788-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CLSTN1 Fusion Protein Ag3504 (29-350 aa encoded by BC033902)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ARVNKHKPW LEPTYHGIVT ENDNTVLLDP PLIALDKDAP LRFAGEICGF KIHGQNVPFD AVVVDKSTGE GVIRSKEKLD CELQKDYSFT IQAYDCGKGP DGTNVKKSHK ATVHIQVNDV NEYAPVFKEK SYKATVIEGK QYDSILRVEA VDADCSPQFS QICSYEIITP DVPFTVDKDG YIKNTEKLNY GKEHQYKLTV TAYDCGKKRA TEDVLVKISI KPTCTPGWQG WNNRIEYEPG TGALAVFPNI HLETCDEPVA SVQATVELET SHIGKGCDRD TYSEKSLHRL CGAAAGTAEL LPSPSGSLNW TMGLPTDNGH DSD (29-350 aa encoded by BC033902)
靶标信息
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alc-alpha; alcadein alpha; Alcadein-alpha; Alzheimer-related cadherin-like protein; cadherin-related family member 12; Calsyntenin-1; FLJ32258; Non-classical cadherin XB31alpha
基因别名: 1810034E21Rik; ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CLSTN1; CS1; CST-1; CSTN1; KIAA0911; PIK3CD; XB31alpha
UniProt ID: (Human) O94985, (Rat) Q6Q0N0, (Mouse) Q9EPL2
Entrez Gene ID: (Human) 22883, (Rat) 313717, (Mouse) 65945
