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Abnova
CNOT2 Polyclonal Antibody, MaxPab™
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CNOT2 Antibody (H00004848-D01P) in WB
Western Blot analysis of CNOT2 expression in transfected 293T cell line (H00004848-T01) by CNOT2 MaxPab polyclonal antibody.
Lane 1: CNOT2 transfected lysate(59.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: CNOT2 transfected lysate(59.70 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004848-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CNOT2 (NP_055330.1, 1 a.a. approximately 540 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF
靶标信息
CCR4-NOT Transcription Complex 2 (CNOT2) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT2 is required for the CCR4-NOT complex structural integrity. It can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. CNOT2 is involved in the maintenance of embryonic stem (ES) cell identity. (UniProt)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; negative regulator of transcription 2
基因别名: CDC36; CNOT2; HSPC131; MSTP046; NOT2; NOT2H
UniProt ID: (Human) Q9NZN8
Entrez Gene ID: (Human) 4848
negative regulation of transcription from RNA polymerase II promoter
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cytoplasmic mRNA processing body assembly
negative regulation of translation
gene silencing by RNA
negative regulation of intracellular estrogen receptor signaling pathway
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of stem cell population maintenance
