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The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: coat protein gamma-cop; coat protein, nonclathrin, gamma-2-cop; coatomer protein complex, subunit gamma 1; coatomer protein complex, subunit gamma 2; coatomer subunit gamma; Coatomer subunit gamma-1; Coatomer subunit gamma-2; Gamma-1-coat protein; Gamma-1-COP; Gamma-2-coat protein; Gamma-2-COP; gamma-coat protein; gamma-COP; testicular secretory protein Li 12
基因别名: 2-COP; AU019265; AW227625; BC056168; COPG; COPG1; COPG2; D6Ertd71e; D6Wsu16e; gamma-2-COP; RGD1566215
UniProt ID: (Human) Q9Y678, (Human) Q9UBF2, (Mouse) Q9QZE5, (Rat) Q4AEF8, (Mouse) Q9QXK3
Entrez Gene ID: (Human) 22820, (Human) 26958, (Mouse) 54161, (Rat) 297428, (Rat) 301742, (Mouse) 54160