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Invitrogen
CREBL2 Polyclonal Antibody
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产品信息
PA5-60489
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human CREBL2
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: REELEMYKQW CMAMDQGKIP SEIKALLTGE EQNKSQQNSS RHTKAGKTDA NSNSW
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 93%.
靶标信息
cAMP response element-binding protein-like-2 was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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