Invitrogen

CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)

Name: CSNK1A1\/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)
Brand: Invitrogen
SKU: MA5-56415

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (9)

CSNK1A1/CSNK1A1L Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

CSNK1A1/CSNK1A1L Antibody (MA5-56415) in ICC/IF

Immunocytochemistry analysis of CSNK1A1/CSNK1A1L with HCT 116 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp). Next they were incubated with CSNK1A1/CSNK1A1L Recombinant Monoclonal Antibody (Product # MA5-56415)at a dilution of 1:500 in 1% BSA in PBST over... View More

CSNK1A1/CSNK1A1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CSNK1A1/CSNK1A1L Antibody in Western Blot (WB)

CSNK1A1/CSNK1A1L Antibody in Flow Cytometry (Flow)

CSNK1A1/CSNK1A1L Antibody in Immunoprecipitation (IP)

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Immunogen image

Immunogen Image CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)

产品信息

MA5-56415

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

免疫组化（石蜡） (IHC (P))

1:1,000

免疫细胞化学 (ICC/IF)

1:500

流式细胞分析 (Flow)

1:1,000

免疫沉淀 (IP)

1-2 µg

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PSH04-58

抗原

Recombinant protein within human CSNK1A1 aa 1-337/337.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_3679470

靶标信息

CSNK1A1 (casein kinase 1 alpha 1) and CSNK1A1L (casein kinase 1 alpha 1-like) are serine/threonine protein kinases involved in various cellular processes. CSNK1A1 is located on chromosome 5 (5q32) and functions as a putative tumor suppressor, playing a role in cell cycle regulation, apoptosis, and autophagy. It is involved in the CGAS-STING pathway, inhibiting the overactivation of type I interferon signaling by promoting autophagic degradation of STING1. Additionally, CSNK1A1 has implications in certain cancers and myelodysplastic syndromes where its regulation affects cell proliferation and sensitivity to therapies. In contrast, CSNK1A1L is a paralog of CSNK1A1 that shares similar functional domains and potentially overlapping functions, although its specific role and regulatory mechanisms remain less characterized. Both genes are involved in critical pathways regulating cell survival and immune response, and their dysregulation is associated with disease states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; casein kinase I-alpha; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p

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基因别名: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1; CK1a; CKIa; Csnk1a; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; PRO2975

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UniProt ID: (Human) P48729, (Human) Q8N752, (Rat) P97633

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Entrez Gene ID: (Human) 1452, (Human) 122011, (Rat) 113927, (Mouse) 93687

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