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Proteintech
CSNK1A1L Polyclonal Antibody
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产品信息
17125-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CSNK1A1L Fusion Protein Ag10814 (1-337 aa encoded by BC028723)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MTNNSGSKA ELVVGGKYKL VRKIGSGSFG DVYLGITTTN GEEVAVKLES QKVKHPQLLY ESKLYTILQG GVGIPHMHWY GQEKDNNVLV MDLLGPSLED LFNFCSRRFT MKTVLMLADQ MISRIEYVHT KNFLHRDIKP DNFLMGTGRH CNKLFLIDFG LAKKYRDNRT RQHIPYREDK HLIGTVRYAS INAHLGIEQS RRDDMESLGY VFMYFNRTSL PWQGLKAMTK KQKYEKISEK KMSTPVEVLC KGFPAEFAMY LNYCRGLRFE EVPDYMYLRQ LFRILFRTLN HQYDYTFDWT MLKQKAAQQA ASSSGQGQQA QTQTGKQTEK NKNNVKDN (1-337 aa encoded by BC028723)
靶标信息
CSNK1A1L serine/threonine kinase or CK1-alpha dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. It governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. These kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins including CTNNB1, PER1, and PER2. CSNK1A1 also participates in Wnt signaling. It may play a role in segregating chromosomes during mitosis, as well as, cytoskeleton diassembly which may regulate epithelial cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha-like; CK1; CKI-alpha-like
基因别名: CK1; CSNK1A1L
UniProt ID: (Human) Q8N752
Entrez Gene ID: (Human) 122011
