Invitrogen

CTLA-4 Monoclonal Antibody (63828)

Name: CTLA-4 Monoclonal Antibody (63828)
Brand: Invitrogen
SKU: MA5-23842

查看其他87个CTLA-4 (CD152)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

图: 1 / 1

CTLA-4 Antibody (MA5-23842) in Neu

Neutralization of CTLA-4 in Jurkat human acute T cell leukemia cell line. Samples were incubated in CTLA-4 monoclonal antibody (Product # MA5-23842). Recombinant Mouse CTLA-4 Fc Chimera inhibits Recombinant Human B7-1/CD80 Fc Chimera induced IL-2 secretion in the Jurkat human acute T cell leukemia cell line in a dose-dependent manner (orange line), as measured by the Human IL-2 Quantikine ELISA Kit. Inhibition of Recombinant Human B7-1/CD80 Fc Chimera (3 µg/mL) activity elicited by Recombinant Mouse CTLA-4 Fc Chimera (1 µg/mL) is neutraliz... View More

Product Image Gallery

Immunogen image

Immunogen Image CTLA-4 Monoclonal Antibody (63828)

产品信息

MA5-23842

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

流式细胞分析 (Flow)

2.5 µg per million cells

中和实验 (Neu)

2.5-10 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

63828

抗原

Mouse myeloma cell line NS0-derived recombinant mouse CTLA-4 Ala36-Phe161

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2609569

产品详细信息

In direct ELISAs, this antibody does not cross-react with recombinant mouse (rm) CD28, recombinant human CTLA-4, rmICOS, or rmPD-1.

Reconstitute at 0.5 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

靶标信息

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。